Endocrine Abstracts

The basis of the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is insulin resistance (IR) which appears on the background of abdominal obesity (AO) which, in turn, is a key factor in the emergence of an imbalance between adipocytokines entailing a disturbance of lipid and carbohydrate metabolism, which ultimately leads to the damage of the liver cells, the development of inflammation, fibrosis and apoptosis. The goal – to study features of changes in the level ...

Tumour necrosis factor-α (TNF-α) impairs liver function and contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (DM-2) with different trophological status.Purpose: To assess the relationship between the level of TNF-α and indices of carbohydrate metabolism in patients with NAFLD and its combination with DM-2 with different trophological status.Methods:...

Aims: To determine the role of intima–media thickness (IMT) of internal carotid artery (ICA) in the diagnosis of coronary atherosclerosis in patients with type 2 diabetes (T2D) and silent ischaemia (SI).Methods: We provide a retrospective analysis of 60 cases of patients with T2D (24 men, age 60.5±4.7 years), history of diabetes – 4.7±0.5 years. SI was diagnosed by comparing complaints, anamnesis, ECG data and daily ECG monitoring. Al...

The mechanisms of myocardial damage are complex and studied insufficiently in patients with diabetes mellitus type 2 (DM2) with overweight. The contribution of adipokines leptin and resistin into the formation of diastolic dysfunction (DD) in patients with DM2 remains understudied. The purpose of the study was to evaluate the relationship between the state of leptin and resistin activity and DD in patients with DM2 with normal and overweight.Methods: 94 ...

Non-alcoholic fatty liver disease (NAFLD) develops in 75–90% of patients with diabetes mellitus 2 type (DM2) and obesity (Ob). Collagen degradation is regulated by the activity of interstitial collagenases, especially matrix metalloproteinases 1 type (MMP-1). It is necessary to determine levels of tissue inhibitor of metalloproteinases-1 (TIMP-1), which regulates activity of MMP-1.Aim: Optimisation of diagnosis and specification of prognosis of NAFL...

There is a need in study of resistin (R) role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) against the background of metabolic disorders.Aim: To assess the relationship between R and indexes of enzyme and pigment metabolism in patients (pts) with NAFLD combined with diabetes mellitus (DM) type 2 and obesity (Ob).Methods: Fifty pts with NAFLD in combination with subcompensated DM (HbA1c 8.3±1.7%) and Ob (BMI&...

The purpose of the study was to determine the functional state of the gallbladder (GB) in patients with type 2 diabetes mellitus (T2DM) in combination with metabolic syndrome (MS).Methods: 40 patients with T2DM and obesity of I–II degree were examined as well as 20 healthy volunteers. Ultrasonography, dynamic echocholecystography and duodenal intubation were performed. The motor function of GB was assessed by emptying coefficient (Kempt=(Vc</su...

Background: It has been proved that the adipose tissue is an active endocrine organ. It secretes a large number of adipokineswhich are involved in and affect regulation of metabolic process and can influence pathogenesis of atherosclerosis. Vaspin-new representative of adipokineswhich is secreted by adipose tissue and have an insulin-sensitizing properties. Vaspin engagement into atherosclerotic process poorly investigated.Aim: To establish the value of ...

Purposes: To assess the peculiarities of atherosclerotic coronary arteries (CA) lesion in patients with coronary artery disease (CAD) and type two diabetes mellitus (T2DM).Materials and methods: We provide a retrospective analysis of 90 cases of patients with CAD (54 males, aged 60,5±4,7 years). Baseline characteristics of patients included history of CAD (7,2±2,3 years), T2DM (4,7±0,5 years). All patients were divided into two groups: 1st...

Cardiovascular risk (CR) in patients with diabetes mellitus (DM) is high. Arrhythmias (Ar) could increase CR as well. We aimed to define is there any association between hyperglycemia and incidence of Ar. We studied 137 (75 F/62 M) type 2 diabetic patients with coronary artery disease (CAD). The age was 54.0±5.5 years (M±S.D). The CAD and DM duration <10 years was in 64 (47%) and in 47 (34%), 15 years and above – in 21 (15%) and in 34 (25%) re...